WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

  • WJPPS: NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2024 Issue has been successfully launched on NOVEMBER 2024.

Abstract

BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF RIBAVIRIN IN RAT PLASMA BY RP-HPLC METHOD

Dr. Sonali Paresh Mahaparale*, Rasika Pramod Karandikar and Kundan B. Bhalerao

ABSTRACT

A simple, rapid, selective, sensitive, accurate and precise High Performance Liquid Chromatography (HPLC) with UV detection method has been developed and validated for determination of Ribavirin in rat plasma. C18 (250x4.6mm) column was used with the mobile phase containing a mixture of Acetonitrile: Water (60:40v/v). The flow rate was 1ml/min and drug was monitored at 218 nm. Plasma samples were processed using acetonitrile as precipitating agent to extract drug. The linearity for Tolperisone hydrochloride was found to be 0.5 to 12 μg/ml with regression coefficient (r2) 0.9990. The recovery was found to be 88.09%.

Keywords: Ribavirin, Reverse phases HPLC, Accuracy, Precision, Robustness, LOD, LOQ, and Specificity.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More