Abstract

BENZOTHIAZOLE: A MOLECULE WITH BROAD SPECTRUM OF ANTIMICROBIAL ACTIVITY

Taher Patel*, N. Siva Subramaniam, Eshrath and Chikkudu Divya

ABSTRACT

Benzothiazoles are the important pharmacophore and privileged substructures in medicinal chemistry owing to their involvement as a key component for various biological activities. The high profile of biological applications displayed by compounds associated with these nuclei have prompted wide studies for their synthesis a large number of efforts were made to synthesize different heterocyclic compounds a nd their derivatives in the past decade and were found to posses promising antimicrobial activity. Extensive biochemical and pharmacological studies have confirmed that benzothiazole derivatives are effective against various strains of microorganisms. Although benzothiazole moiety is very small but is fascinated by scientists becau se of the due to the structural similarity with purine, antibacterial ability of these compounds manifested their competition with purines resulting in the distinct inhibition of the synthesis of nucleic acids and proteins inside the bacterial cell wall. This review is mainly an attempt to present the research work reported in the recent scientific literature on antimicrobial activitity of benzothiazole compounds.

Keywords: Benzothiazole, Antibacterial activity, Antifungal activity.