Abstract

ANALYSIS OF DE-ESCALATION PATTERN OF ANTIBIOTICS IN CRITICALLY ILL PATIENTS WITH INFECTIOUS DISEASE IN A QUATERNARY CARE HOSPITAL: A RETROSPECTIVE OBERVENTIONAL STUDY

Deepa Poulose*, Jenimol Joseph, Sethu Sugathan, Sophiya T. Varghese, Annamol Joseph, Chinnu K. Antony, Savita Sharma and T. Sivakumar

ABSTRACT

Background: Antibiotic de-escalation is a process for judicious use of antibiotics which helps to reduce the emergence of drug- resistant microorganisms. Objective of the study is to analyze whether deescalation was done in critically ill patients with infectious disease in quaternary care hospital. Methodology: A retrospective interventional study was carried out at a quaternary care hospital in Haryana, North India between February 2016 to April 2017 in which 50 patients meeting the inclusion criteria were selected and analyzed whether deescalation was done on those patients based on antibiogram of the institution, patient condition and microbiological report. Results and Discussion: Out of 50 patients included in the study, except for one patient the culture was sent within 72 hours after starting antibiotics. Antibiotic de-escalation must be done in both culture positive and culture negative patients, 86% of culture positive and 71% of culture negative patients have undergone de-escalation in this study. Conclusion: Inappropriate use of antibiotics leads to emergence of resistance, worsen the clinical condition and increased healthcare costs. Therefore it should be mandatory to obtain reliable specimens from the infection site of the patient in order to de-escalate antibiotics.

Keywords: De-escalation, Antibiogram, Antibiotics, Resistance.