Abstract

SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF ABACAVIR SULFATE AND LAMIVUDINE IN TABLET DOSAGE FORM

Pallavi Duse*, Mokale S. N and Tanvi Pingale

ABSTRACT

Two simple, accurate and economic methods Area under curve and Multicomponent have been described for the simultaneous estimation of Abacavir and Lamivudine in tablet dosage form. Abacavir shows absorption maximum at 284.0nm and Lamivudine shows absorption maximum at 270.0nm in distilled water. Beers law was obeyed in the concentration range of 5-30 μg/ml for Both Abacavir and Lamivudine. The coefficient correlations were found to be 0.9995 for LAM and 0.9992 for ABAC respectively.The method allows rapid analysis of binary pharmaceutical formulation with accuracy. Results of Tablet analysis by Multicomponent method was found to be 99.99% for ABAC and 100.03% for LAM while by AUC method it was found to be 99.99% for ABAC and 99.97% for LAM respectively. Results of analysis of two methods were validated statistically and by recovery studies and were found satisfactory.

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