Abstract

A RETROSPECTIVE STUDY IN LEBANON. THYROID-STIMULATING HORMONE AND ITS POSSIBLE ASSOCIATION WITH SERUM LIPIDS

Hala Khalife, Hassan Khalife, Samaya Farhat, Hussein Khalife and Fadi Abdel-Sater*

ABSTRACT

Thyroid gland diseases are a public health problem worldwide. Many disorders result from the imbalance in the regulation of thyroid hormones, these ranges from a small goiter to life threatening diseases, like thyroid cancer. Until these days, the relationship between thyroid stimulating hormone and hyperlipidemia remained a topic of debate. The aim of this study is to examine the influence of gender and age on the association between serum TSH and lipid profile among a population in Beirut. The present study includes the results derived from analyzing TSH and serum lipids levels of 776 individuals including 567 females and 209 males aged between 5 and 80 years. This was achieved by collecting data from different laboratory databases over an 8-year period from 2009 till 2016. Our results showed a significant association between gender and TSH levels where f females have a significant higher risk than males. Moreover, the risk of hypothyroidism increases with age in both genders with the highest prevalence rate was found in the females between 41 and 50 years old and the males between 51 and 60 years. Furthermore, TSH was associated with hypertriglyceridemia and high serum low-density lipoprotein-cholesterol in all patients studied. However, no significant relationship was observed between high TSH and hyperlipidemia in male subjects considered alone. Concerning female cases, a significant association was observed between high TSH and high triglyceride levels only. Further understanding requires additional population-based studies to better assess and compare different results.

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