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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION STUDIES FOR THE ESTIMATION OF ABACAVIR AND LAMIVUDINE IN BULK AND FIXED DOSE COMBINATION (TABLETS) BY RP-HPLC
*M. Gayathri Devi, W. A. Umarani and Dr. G. Sudhakara Rao
ABSTRACT
A new RP-HPLC method for the quantitative determination of Abacavir and Lamivudine was developed and validated as per ICH guidelines. The drugs were injected into inertsil ODS C18 column (150×4.6, 5 m), maintained at ambient temperature and effluent monitored at 228 nm. The mobile phase consisted of phosphate buffer: acetonitrile [HPLC grade] (70: 30V/V). The flow rate was maintained at 1.0 mL/min. The developed method shows high specificity for Keywords: Abacavir and Lamivudine. [Download Article] [Download Certifiate] |