Abstract

COLISTIN-INDUCED NEPHROTOXICITY: A CASE REPORT

Dr. Priya Thomas*, Dr. Chinnu Reeba George, Dr. Jessy Thomas, Dr. Sachin S. Jadhav and Dr. Mahesh Rajashekaraiah

ABSTRACT

Colistin, also known as Polymyxin E, re-introduced into clinical practice due to emergence of resistance of gram negative pathogens to existing therapeutic options. But its adverse effects such as nephrotoxicity and neurotoxicity still remain an inevitable issue. This is a case report of colistin induced nephrotoxicity happened in an young male patient with aplastic anemia. Factors that influence the risk of colistin nephrotoxiciy are age, dose and duration of therapy. Maintenance doses of colistin require adjustment according to renal function because even at a specific creatinine clearance there is very large interpatient variability in the plasma colistin concentration and this makes colistin dose selection difficult. Therapeutic drug monitoring of polymyxins is needed as it can assist in optimising dose regimens and minimise the development of polymyxin-induced nephrotoxic effects.

Keywords: Colistin, also known as Polymyxin polymyxin-induced nephrotoxic effects.