Abstract

ANTIDEPRESSANT ACTIVITY OF METHANOLIC EXTRACT OF PYRUS PASHIA LEAVES IN RATS

Neha Pandey, Anita Singh* and Janmejay Pant

ABSTRACT

The objective was to investigate the antidepressant activity of methanolic extract of Pyrus pashia leaves (MEPPL) in albino rats. In this study rats were separated into 4 groups (n=6/group), 1st group was denoted as control group in which only distilled water was used, 2nd group was denoted as standard group in which Imipramine hydrochloride (15mg/kg) was used as standard and rest 2 groups were denoted as test groups (T1, T2). Two doses of the methanolic extract of Pyrus pashia leaves (MEPPL) (100 and 200 mg/kg) were used as T1 and T2 respectively. Control, standard and test samples (Imipramine and dried extract of Pyrus pashia leaves) were administered via gavage through oral route (p.o). The outcomes demonstrated that a dose dependent antidepressant activity in FST and LMA. The fundamental discoveries of the MEPPL altogether reduced the immobility times in the FST (p

Keywords: Pyrus pashia, Antidepressant Activity, Forced Swim Test, Locomotors Activity.