Abstract

SYNTHESIS, SAR STUDIES AND EVALUATION OF NOVEL BENZOTHIAZEPINES AS ANTIMICROBIAL AGENTS

Dr. Bushra Ahmed Kateb*, Abdulkareem Ali Hussien and Santosh M. More

ABSTRACT

Microbiology, Yeshwant Mahavidyalaya, Nanded-431602. ABSTRACT One of the most widely employed methods for the preparation of 1,5- benzothiazepines involve the reaction of 2-aminothiophenol with 1, 3- dicarbonyl compounds. A series of 1,5-benzothiazepines have been Synthesized by the reacting of 2-aminothiophenol benzaladehyde and 2,4-pentane-dione, Aluminum Nitrate(10 mol%) in 20 ml ethyl alcohol. The synthesized benzothiazepines were characterized by Physical and spectral methods such as melting point, IR, 1H-NMR and Mass analysis. All the synthesized compounds have been screened and evaluated for antibacterial activity against Staphylococcus aureus gr +ve, Escherichia coli gr –ve Bacillus subtilis gr +ve, Salmonella typhi gr –ve, and antifungal activity against Aspergillus oryzoe, Aspergillus niger,. DMSO was used as a solvent control for their antimicrobial activity using disc diffusion method. Synthesis and biological evaluation of 1,5-benzothiazepines derivatives have been a topic of special interest to organic and medicinal chemists.

Keywords: 2-aminothiophenol, 2,4-pentane-dione, SARstudies, Antibacterial activity.