Abstract

A REVIEW ON: - MOUTH DISSOLVING DRUG DELIVERY SYSTEM

Sapna M. Ragade* Akash A. Jain and Dr. Shashikant Barhate

ABSTRACT

Swallowing a pill is a major difficulty encountered in case of geriatric and pediatric patient which leads to poor patient compliance due to unpalatable taste of drug. To troubleshoot these problems a new dosage form known as moutht-dissolving tablet (MDT), has been developed which rapidly disintegrate and dissolve in saliva. MDT are intended and designed to disintegrate and dissolve in saliva and then easily swallowed without need of water which is a major benefit over conventional dosage form. These dosage forms are also used to attain instant a higher concentration of drug in body for immediate actions. Mouth dissolving tablets can be prepared by using various conventional methods like direct Compression, wet granulation, moulding, spray drying, freeze drying, and sublimation method and by using different type of superdisintegrants like Cross linked carboxymelhylcellulose (Croscarmeliose), Sodium starch glycolate (Primogel, Explotab), Polyvinylpyrrolidone (Polyplasdone) etc. This review discusses the method of preparation, properties, advantages, disadvantage, characterization, mechanisms; drugs to be incorporated in the mouth dissolving tablet. Technologies used for manufacturing of orally disintegrating tablets are either conventional technologies or patented technologies. In conventional freeze drying, tablet molding, sublimation, spray drying etc. and in patented technology such as Zydis, Orasolv, Durasolv, Wowtab and Flashdose technology are important. Important ingredients that are used in the formulation of ODTs should allow quick release of the drug, resulting in faster dissolution. This review describes.

Keywords: Mouth dissolving tablets, Conventional techniques, patented technology.