Abstract

INVESTIGATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEM

*Shivah Karamian

ABSTRACT

Gastroretentive Drug Delivery System, comprising mainly of floating, bioadhesive and swellable systems have emerged as an efficient means of enhancing the bioavailability and controlled release delivery of drugs exhibiting absorption window. Gastroretentive drug delivery is an approach to prolong gastric residence time, thereby targeting site-specific drug release in the upper gastrointestinal tract (GIT) for local or systemic effects. Gastroretentive dosage forms can remain in the gastric region for long periods and hence significantly prolong the gastric retention time (GRT) of drugs. This ensures maximum absorption of the drug for the desired period. Designing of a Gastroretentive Drug Delivery System, requires a thorough understanding of physicochemical properties of drug, physiological events in GI tract and formulation strategies. A careful consideration of interplay of these parameters can help in designing Gastroretentive Drug Delivery System, which meet their objectives successfully. Growing understanding of impact of GI tract physiology on drug delivery and increasing sophistication of delivery technology will ensure development of an increasing number of Gastroretentive Drug Delivery System to optimize drug delivery of molecules exhibiting regional variability in intestinal absorption.

Keywords: Gastroretentive, Oral controlled release, Floating dosage form, Drug delivery system.