Abstract

FLOATING GRANULES: NEW CONCEPT IN GRDS

Girish S. Vispute*, Anil P. Palhal, Piyush S. Mahajan, Dr Surajj Sarode and Dr. Shashikant Barhate

ABSTRACT

Gastroretentive drug delivery system has been a significant approach over the past few years that have been noted to prolong gastric residence time, thereby targeting site-specific drug release in the upper gastrointestinal (GI) tract for local or systemic effects. The present study has been investigated to compile the recent as well as past literature with special focus on various gastroretentive approaches that have recently become leading methodologies in the field of site-specific orally administered controlled release drug delivery. Floating systems have been considered as one of the imperative categories of drug delivery systems with gastric retentive behavior. The review article explains the various floating drug delivery systems that are formulated in order to enhance the drug bioavailability. Moreover, various gastroretentive approaches designed and developed such as high density, floating, bioadhesive, super porous hydrogel and magnetic systems have been clearly discussed in the article.

Keywords: Gastroretentive, Drug delivery system, Floating systems.