Abstract

ADVANCES IN CONTROLLED RELEASE TECHNOLOGY IN PHARMACEUTICALS: A REVIEW

Puja Saha* and Pratik Swarup Das

ABSTRACT

Controlled drug delivery systems have been developed to improve the next staging of the drug in the body with two main purposes: to reduce the number of single doses per day improving patient compliance of treatments and to decrease the fluctuations of plasma levels, in order to obtain better therapeutic efficacy and lower toxicity. They can play a significant role in targeted drug delivery system in organ or tissue. In Controlled drug delivery system, more than one mechanism may be involved at different stages of drug pharmacokinetics and pharmacodynamics profiling. Some drug delivery systems have been formulated and are being investigated. These types of the system had some advantage over traditional drug delivery system, including short time of drug release protection of breakable drugs and increased patient comfort and compliance. The review underlines the methodology of controlled drug delivery system preparation, their significance, disadvantages, detailed classification and the relevant example wherever required are demonstrated.

Keywords: Controlled Drug Delivery, Dose, Efficacy, Toxicity, Pharmacokinetics, Pharmacodynamics, Compliance.