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FORMULATION AND EVALUATION OF BUCCAL FILM OF ROSUVASTATIN
Shivani Saxena* and Dr. Sobhna Singh
ABSTRACT
For systemic drug delivery, the buccal region offers an attractive route for drug administration. The main objective of the study is to formulate buccal films of rosuvastatin. Rosuvastatin is a HMG Co-A inhibitor used for the treatment of hyperlipidaemia, atherosclerosis disease. It’s oral bioavailability is 20% due to extensive first pass metabolism. Rosuvastatin films were prepared using HPMC, CMC and PVA, Tragacanth in various proportions and combinations using Glycerine as a plasticizer. Citric acid was used to enhance the penetration of buccal film. The surface pH of films ranged between 6 and 7. The thickness of medicated patches was ranged between 0.24 and 0.39 mm. The tensile Keywords: HPMC, CMC, PVA, Tragacanth (polymers), Buccal film, Hyperlipidaemia, Atherosclerosis, Rosuvastatin. [Download Article] [Download Certifiate] |