Abstract

EVALUATION OF HYPO LIPIDEMIC AND ANTIOXIDENT PROPERTIES OF METHANOLIC EXTRACT OF LEAVES OF RUELLIATUBEROSA LINN ON MITHIONINE AND TRITON INDUCED MODELS IN WISTER ALBINO RATS

K. Naga Rani*, B. Anitha and P. Venkateswara Rao

ABSTRACT

In this modern world we are exposed to various factors which disturb homeostasis of our body physiology, leads to the development of various disease as its end point. Among the various diseased conditions less percentage of diseases were cured, in case of the remaining disease conditions only their symptoms are reduced instead of complete cure. Eg: AIDS, Cancer, Diabetic mellitus, Hypertension and hytperlipidmia. Among the various dreadful diseases, Hyperlipidimia is one the major disease affecting all age of people having a mortality rate of about 5% of all human deaths and 80% diseases caused do to this hyperlipidmia. The present synthetic Anti hyperlipidimic drugs produce undesirable side effects and treatment is cost effective. The plants selection in the present study was done on basis of it easy availability and phytochemical constituents to screen their therapeutic potential. The plant Plumeria acuminata Linn contain alkaloids, flavonoids, steroids, phenol and other constituents. The Methanolic extract of Ruellia tuberosa Linn possess phytochemicals with reported antioxidant activity, the formulation was screened for anti-oxidant activity by catalase assay and has significant free radical scavenging activity. Studies lead to the conclusion that herbal extract of the whole plant Ruellia tuberosa Linn could be used for the treatment of hyperlipidemia, as they are found to be potent and safe in pre-clinical study. However elucidation of exact mechanism of action of beneficial effects of these formulations needs further investigation. More randomized controlled trials in large patient populations have to be carried out before determining the status of these drugs in the therapy of hyperlipidemia.

Keywords: Hyperlipidimia, Plumeria acuminata, Methanolic extract, Ruellia tuberosa, Anti hyperlipidimic drugs.