Abstract

CHARACTERISATION AND COMPARISON OF DRUG RELEASE FROM GLICLAZIDE MICROCAPSULES PREPARED USING NATURAL AND SYNTHETIC POLYMERS

Lakshmi Usha Ayalasomayajula*, Radha Rani Earle, M. Nishitha, K. Mounika, D. Anil

ABSTRACT

Microcapsules are one of the multi particulate delivery system to achieve sustained or controlled release drug delivery to improve bioavailability and stability of drug. Hence an attempt was made to prepare mucoadhesive microcapsules of gliclazide designed for oral controlled release. The main objective of the study is to extend drug release, for the treatment of type II diabetes and to reduce dosing frequency. The aim of the present investigation was to formulate and evaluate microcapsules of gliclazide using ion gelation method. Gliclazide microcapsules were prepared using sodium alginate and polymers such as HPMC and GUAR GUM in the ratio of 1:1, 1:2, 1:3. It was found that formulation containing drug and polymer (HPMC) in the ratio 1:2 showed maximum % of the drug released within 18 hrs. The results were also based on particle size analysis and micromeriticproperties like Angle of repose, Bulk density, Carr’s index, Hausner’s ratio and percentage yield. They were also evaluated for their enacapsulation efficiency and in vivo dissolution studies. The microcapsules were discrete, spherical and free flowing. Compatibility studies like DSC and FTIR were also performed for the samples which showed no drug interaction.

Keywords: Gliclazide, Diabetes, Microencapsulation, Ion-gelation method, Hydroxypropyl methyl cellulose, Guar gum.