Abstract

FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING DOSAGE FORM OF NIZATIDINE

Sachin B. Aglawe* and Amol U. Gayke

ABSTRACT

The objective of the present investigation is to formulate gastroretentive dosage form of Nizatidine, widely prescribed in gastric and duodenal ulcers. The short biological half-life (1 - 2 hours), maximum absorption in initial part of small intestine, colonic metabolism of Nizatidine favors’ development of gastro retentive floating dosage form. In the present study sodium bicarbonate is use as a gas generating agent. The tablets were formulated using direct compression technology by employing semi synthetic polymers like HPMC K15M, and Sodium alginate. The prepared tablets were evaluated for various physicochemical parameters such as flow properties, hardness, weight variation, friability, in vitro buoyancy (floating lag time, total floating time), swelling studies, drug content and in-vitro drug release. Out of all formulations the one prepared with combination of HPMC K15M and Sodium alginate was optimized based on desired sustained release time (12hrs) and acceptable floating properties. The development of controlled-release formulations continues to be a big success for the Pharmaceutical Industry. The success of any technology relies on the ease of its manufacturing process and its reproducibility of desirable biopharmaceutical properties.

Keywords: Nizatidine, HPMC K15M, Sodium alginate, sodium bicarbonate, Floating Tablets, Direct compression method.