Abstract

EXTRACTION OF ACETYLCHOLINESTERASE INHIBITORS FROM PETREA VOLUBILIS AND SCREENING OF ITS ACTIVITY ON ZEBRAFISH

Pooja Arya, Guruprasad R.* and Rashmi Rekha Tripathy

ABSTRACT

Acetylcholinesterase is an enzyme which breakdown the neurotransmitter acetylcholine into acetic acid and choline in cholinergic neurons. In neurodegenerative diseases like Alzheimer’s disease and Parkinson’s disease there is shortage of neurotransmitter acetylcholine in the brain. Therefore inhibition of acetylcholinesterase enzyme is required to slow down the progression of these diseases. Plants have naturally occurring compounds which have acetylcholinesterase inhibitory activity therefore a study was conducted to find out the acetylcholinesterase inhibitory activity of the methanolic extract of Petrea volubilis. The compounds present in petrea volubilis showed good binding affinity with acetylcholinesterase enzyme and the methanolic extract showed reduction in the activity of acetylcholinesterase both in vitro and in vivo conditions. So it was concluded that Petrea volubilis have inhibitory effect on the activity of acetylcholinesterase.

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