Abstract

NATURAL ORAL FORMULATION OF MEDORRHINUM MICRO-DROPLETS COMPOSITES FOR CHRONIC RHEUMATOID ARTHRITIS

Vinay Kumar Thangellapelli and Dr. Rakesh Das*

ABSTRACT

Objective: An innovated, compatible, and complete cure of Rheumatoid arthritis through Medorrhinum extract formulated with natural encapsulated fruit (Raisin) without incorporating any outside ingredients. This is first orally chewable natural fruit capsule with naturally fruit inbuilt preservative. It totally eradicates disease by empowering autoimmune system with natural medication adherence for patients. Materials and Method: This drug was cultured, extracted, isolated, purified, concentrated, formulated, therapeutically validated & evaluated in mice. Therapeutic effects were evaluated in 3 mice group- without drugs, with 1 drop & with 2 drops administration to identify retention/holding time of mice in rotating Rota rod. And clinically designed & tested in 18 acute & chronic patients. Result and Discussion: Its therapeutic index is very high, because the effective drug concentrated in doses (2 drops) recommended for adult human itself is found to be safe for mice. The intraday mean value retention/holding time (i.e., to understand the improvement in mobility on rectifying articulate joints defects) on the three groups (each group has 3 mice) from 9:30 am – 2:30 pm on 1hr interval of mice showing the mean values of 5.17 ± 0.89, 43.03 ± 1.69, 74.25 ± 1.55 (in Sec.). The inter-day mean value retention/holding time on three consecutive days was evaluated showing a vast difference which mean to be highly improved healing status with dates. Conclusion: Medorrhinum is naturally formulated in fruit Raisin, which is found to be safe without any adverse & side effects on evaluating in mice. On clinical investigation it seems to be compatible with natural medication adherence for patients. The drug was successfully evaluated for its safeties in mices on same dose referred to human. On formulation which also sounds natural good medicine adherence. This formulation clinically completely heals patients and assist no chance for disease returns.

Keywords: Lethal dose test Safety, Raisin fruit formulation, Animal studies, irreversible Anti-rheumatic arthritis.