Abstract

A REVIEW ON RESEALED RBCS

*Poonam Ankush Jadhav and Sunil Ankush Jadhav

ABSTRACT

Application of erythrocytes as promising slow drug release or site targeted delivery system for a variety of bioactive agents from different fields of therapy has gained a remarkable degree of interest in recent years. Resealed erythrocytes are gaining more popularity because of their ability to circulate throughout the body, biocompatibility, zero order release kinetics, reproducibility and ease of preparation. Carrier erythrocytes have been evaluated in thousands of drug administration in humans proving safety and efficacy of the treatments. Carrier erythrocytes, resealed erythrocytes loaded by a drug or other therapeutic agents, have been exploited extensively in recent years for both temporally and spatially controlled delivery of a wide variety of drugs and other bioactive agents owing to their remarkable degree of biocompatibility, biodegradability and a series of other potential advantages. Among the various carriers used for targeting drugs to various body tissues, the cellular carriers meet several desirable in clinical applications, among the most important being biocompatibility of carrier and its degradation products. Leucocytes, platelets, erythrocytes, nanoerythrocytes, hepatocytes, and fibroblasts etc. have been proposed as cellular carrier systems. Among these, the erythrocytes have been the most investigated and have found to possess greater potential in drug delivery. Most of the resealed erythrocytes used as drug carriers are rapidly taken up from blood by macrophages of reticuloendothelial system (RES) which is present in liver, lung, and spleen of the body. Carrier erythrocytes are prepared by collecting blood sample from the organism of interest and separating erythrocytes from plasma. By using various methods the cells are broken and the drug is entrapped into the erythrocytes, finally they are resealed and the resultant carriers are theb called “resealed erythrocytes” current review highlights.

Keywords: Resealed Erythrocytes, Carrier, Isolation.