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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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WJPPS Invited to submit your valuable manuscripts for Coming Issue.

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New Impact Factor

WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

Scope Indexed

WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

BIOCHEMICAL AND PATHOPHYSIOLOGICAL ASPECTS OF THE TREATMENT OF HEPATIC ENCEPHALOPATHY IN RATS

Zahran F., Heibashy M. I. A., Mazen G. M. A. and Mobasher E. E.*

ABSTRACT

Hepatic encephalopathy (HE) represents a diverse spectrum of complex neuropsychiatric disturbance resulting from liver disease and its concomitant metabolic and immunologic derangements. Hyperammonemia and inflammation cooperate to induce neurological alteration in hepatic encephalopathy. This study was conducted to elucidate the changes of serum, liver and brain proinflammatory cytokines in encephalopathy rats and to evaluate the hepato-protective activity of lactulose and/or taurine against thioacetamide (TAA) induced hepatic encephalopathy in rats. Acute hepatic encephalopathy (HE) in rats was induced by intraperitoneal injection of thioacetamide in 24 hours intervals for two consecutive days. The obtained results revealed a significant (p

Keywords: Hepatic encephalopathy - Cytokines - S100? - Lactulose - Taurine - Rats.

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