Abstract

COMPARATIVE HPLC STUDY OF RELEASE KINETICS OF THE COCRYSTALLIZED AS WELL AS MIXTURE OF ACTIVE PHARMACEUTICAL INGREDIENTS OF ASPIRIN, IBUPROFEN, INDOMETHACIN, DICLOFENAC SODIUM AND PARACETAMOL IN BODY FLUIDS

*Prof. Dr. Dhrubo Jyoti Sen

ABSTRACT

Aspirin, Ibuprofen, Indomethacin, Diclofenac sodium and Paracetamol are taken as NSAIDs. All drugs have free carboxylic acid group (–COOH) and paracetamol has free phenolic group (–OH) so all are acidic in nature. The combination of drugs is treated for HPLC as well as for codrug: Aspirin & Paracetamol, Ibuprofen & Paracetamol, Indomethacin & Paracetamol, Diclofenac & Paracetamol and Ibuprofen & Diclofenac. Aspirin & Paracetamol, Ibuprofen & Paracetamol, Indomethacin & Paracetamol, Diclofenac & Paracetamol and Ibuprofen & Diclofenac codrugs are formed by hydrogen bonding, ionic interactions, Van der Waals interactions and π–interactions. HPLC study was performed for all individual mixtures as well as codrugs of these and Rt values were recorded. It has been proved that Rt values of mixture are greater than Rt of cocrystallized products.

Keywords: Aspirin, Ibuprofen, Indomethacin, Diclofenac sodium, Paracetamol, Mobile phase, TLC–Rf value, HPLC–Rt value, API, Mobile phase, Co–crystallization, Hydrogen bonding, Ionic interactions, Van der Waals interactions, ?–interactions.