FORMULATION AND EVALUATION OF TETRACYCLINE NIOSOMAL TOPICAL GEL DRUG DELIVERY SYSTEM
Sorlin Selva Joice P.*, Rubina Reichal C., Thirumoorthy N. and Sangeetha M.
ABSTRACT
The core objective of the present study is to formulate Tetracycline niosomes for topical delivery system by hand shaking method. The prepared niosomes are to be characterized for their size, shape, stability, entrapment efficiency, invitro drug release and retention study. The formulation 1(F1) was more stable when compared to other formulations with smaller size vesicles and showed higher entrapment efficiency. The best formulation was prepared as gel with suitable gel base. The Tetracycline Niosomal gel delivery may reduce the frequency of dosing intervals and improve patient compliance.
Keywords: Tetracycline, Niosomal Gel, Topical Drug Delivery, Acne Vulgaris.
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