Abstract

FORMULATION AND EVALUATION OF QUINAPRIL SUSTAINED RELEASE MATRIX TABLETS

Mogal Muktiyar*, M. V. Jhansipriya and Narapusetty Naidu

ABSTRACT

The present investigation was undertaken to design, formulate and evaluate Quinapril matrix tablets for sustained release dosage form. The blends of different formulations were evaluated for angle of repose, bulk density, tapped bulk density, compressibility index and hausner’s ratio. Quinapril sustain release matrix tablets were subjected to various evaluation studies such as average weight, weight variation, thickness, drug content and friability. The drug content of all the tablet formulations lies within the acceptable range of 96.3-100.2%. In vitro dissolution studies of the formulations F1 to F10 of sustained release tablets of Quinapril were carried out in 0.1N HCl & pH 6.8 phosphate buffers. The dissolution profile revealed that as the viscosity polymer increases, release rate get decreased. It was concluded that, the high viscous polymers better retard the release rate when compared to usage of low viscous polymers. From the compatability studies it was concluded that there was no interaction between the polymers and drug.

Keywords: Quinapril, Sustained release dosage form, Matrix tablets.