Abstract

FORMULATION AND INVITRO EVALUATION OF TOPICAL ETHOSOMAL GELS OF MICONAZOLE NTRATE

*Bala Tripura Sundari and Navya S.

ABSTRACT

The aim of the study is to develop Miconazole nitrate loaded ethosomal gel for better antifungal activity by sustaining the drug release and to lower the adverse effects. Miconazole nitrate is an imidazole antifungal drug and is used for the treatment of local and systemic fungal infection. Miconazole topical formulation is made for better patient compliance and to reduce the dose of drug. Miconazole nitrate ethosomes were prepared by hot method using soya lecithin, ethanol and cholesterol in different ratios. They were evaluated for particle size, entrapment efficiency and invitro drug release. Selected ethosomal formulation showed an entrapment efficiency of 88.2% and drug release of 85.3% in 8 hrs. The selected formulation was incorporated in to gel using Carbopol 934, HPMC K4M. Selected ethosomal gel (EG1) showed a drug content of 95.67% and drug release of 85.77% in 8 hrs.

Keywords: Ethosomes, Miconazole nitrate, Ethanol, Soya lecithin, Carbopol 934, HPMC K4M.