Abstract

ANTI-TUBERCULAR ACTIVITY OF SILVER NANOPARTICLE SYNTHESIZED FROM THE FRUITS OF CORIANDRUM SATIVUM LINN

Padmaa M. Paarakh*

ABSTRACT

Tuberculosis has become a major global health problem mainly in developing countries of Asia and Africa including India. Due to the usage of antibiotics, challenge of multidrug resistant TB has increased drastically. So, there is a need for discovery of new anti-TB drugs which are safe, effective and affordable. Medicinal plants have known to be the potential source for the treatment of many ailments. Hence, the present study is designed to investigate the in vitro activity of silver nanoparticle synthesised from the fruits of Coriandrum sativum and methanol and aqueous extracts of the fruit have been evaluated against Mycobacterium tuberculosis H73Rv strain using Micro plate Alamar Blue Assay (MABA). The results revealed that the silver nanoparticle showed sensitivity against M. tuberculosis strain at a concentration 1.6 μg/ml, while methanol extract and aqueous extracts were resistant even at 100 μg/ml concentration. The present investigation suggests that silver nanoparticles synthesized from the fruit of Coriandrum sativum possess remarkable anti-tubercular activity.

Keywords: Mycobacterium tuberculosis, silver nanoparticle, Coriandrum sativum fruit, methanol extract, aqueous extract, in vitro, MABA, H37Rv.