Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NEW DIHYDROPYRIMIDINE DERIVATIVES OF METHYL-3-CYCLOPROPYL-3-OXO-PROPANOATE NUCLEUS

V. R. Dangar*, M. C. Patel and V. R. Shah

ABSTRACT

Many aryl substituted 3,4-dihydropyrimidin-2-ones and their derivatives are an important class of compounds in the field of drugs and pharmaceuticals. Dihydropyrimidine derivatives like some new 4-Aryl-5-carboxymethyl-6-cyclopropyl-3,4-dihydropyrimidine-2(1H)-ones (1a-l) and 4-Aryl-5-carboxymethyl-6-cyclopropyl-3,4-dihydropyrimidine-2(1H)-thiones derivatives of type (2a-l) have been prepared by the cyclocondensation of methyl-3-cyclopropyl-3-oxo-propanoate with arylbenzaldehydes urea and thiourea respectively in the presence of HCl. All the prepared compounds were characterized by their spectral (I.R., N.M.R., Mass) data and screened for their antimicrobial activities.

Keywords: Methyl-3-cyclopropyl-3-oxo-propanoate, Arylaldehydes, Dihydropyrimidines derivatives, Antimicrobial activities.