Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF SOME IMINE ANALOGS

*Dr. Renu Dixit

ABSTRACT

A series of imine analogs were synthesized by the condensation of 3-methoxy 4-hydroxy benzaldehyde with substituted amines in ethanol. The structures of newly synthesized compounds were characterized by IR and 1HNMR spectroscopy. The purity of the synthesized imines analogs has been ascertained by thin layer chromatography using an acetone-n-hexane mixture (1:3). Antibacterial activity of imines was tested against a panel of sensitive and resistant Gram-positive and Gram-negative strains using disc diffusion assay.

Keywords: Vanillin, substituted amines, antibacterial activity.