Abstract

STUDIES IN THE ANTIMICROBIAL ACTIVITIES OF SOME NEWLY SYNTHESIZED TRIAZINES BY DISC DIFFUSION METHOD AND MIC METHODS

Dr. A. S. Shendge, D. T. Tayade* and P. R. Kale

ABSTRACT

2-Thiol-3-ethyl-4-ethylamino-6-[2-isobutoxy-5-(4-methyl-5-carboxy-1,3-thiazo-2-yl)]-phenyl-1,3,5-triazine (A6), 2-thiol-3-ethyl-4-tert-butylamino-6-[2-isobutoxy-5-(4-methyl-5-carboxy-1,3-thiazo-2-yl)]-phenyl-1,3,5-triazine (A7), 2-thiol-3-ethyl-4-p-chlorophenylamino-6-[2-isobutoxy-5-(4-methyl-5-carboxy-1,3-thiazo-2-yl)]-phenyl-1,3,5-triazine (A8), 2-thiol-3-ethyl-4-o-tolylamino-6-[2-isobutoxy-5-(4-methyl-5-carboxy-1,3-thiazo-2-yl)]-phenyl-1,3,5-triazine (A9), 2-thiol-3-ethyl-4-m-tolylamino-6-[2-isobutoxy-5-(4-methyl-5-carboxy-1,3-thiazo-2-yl)]-phenyl-1,3,5-triazine (A10), i.e. were synthesized and its antimicrobial activities were tested against E.Coli, B.Subtilis, S.Typhi, S.Aureus, P.Vulgaris, A.Aerogenes by Disc diffusion method and MIC methods. These compounds showed good results.

Keywords: E.Coli, B.Subtilis, S.Typhi, S.Aureus, P.Vulgaris, A.Aerogenes.