Abstract

SPECTROPHOTOMETRIC STUDY OF COMPLEXATION OF LABETALOL WITH SOME TRANSITION METAL IONS

Dr. Namita Bhardwaj* and Jaishri Kaushik

ABSTRACT

UV- Visible spectrophotometric is a selective method for determination of the complexation of antihypertensive drug labetalol with Cu, Zn, Cd Metal ions. The proposed method is based on the formation of stable Cu(ll), Zn(ll),Cd(ll) complexes with labetalol, labetalol react with these metal ion in aqueous buffer solution where by a coloured complex are formed which absorbed maximally at 350 nm. The different experimental parameters affecting the development and stability of the colour were carefully studied and optimized. Here the selected drug is β-blocker having amino group so the chealation with cu (ll) ion is easily and stable.

Keywords: complexation, spectrophotometric, absorbance, labetalol, Stability, antibiotics.