Abstract

COMBINATION THERAPEUTIC INFLUENCE OF ASPIRIN AND RIVASTIGMINE ON SCOPOLAMINE INDUCED ALZHEIMER’S IN WISTAR RAT

Sudhakar Pachiappan*, Suchithra K. B., Suganeswari M. and Preetu Shukla K. M.

ABSTRACT

Objective: To investigate the combination therapeutic influence of aspirin and rivastigmine on scopolamine induced alzheimer’s in rats. Materials and Methods: Twenty four male Albino Wistar Rats were enrolled in this study and are divided into 4 groups (six each). Memory impairment was induced by administration of scopolamine (1 mg/kg intraperitoneally). Group-I; receives normal saline, Group-II; receives scopolamine (1.0mg/kg/day i. p.), Group-III; Rivastigmine (0.3mg/kg/day p. o.) + Scopolamine (1.0 mg/kg day i. p.), Group-IV; Aspirin (6.75mg/kg/day p. o.) + Rivastigmine (0.3mg/kg/day p. o.) + Scopolamine (1.0 mg/kg/day i. p.) all the treatment carried out daily for 14 days. Cognitive and condition avoidance response was evaluated by using Morris Water Maze (MWM) and Pole climbing apparatus respectively. On 14th day brain was isolated for biochemical and Histopathological examination. Results: In this study, Rivastigmine and aspirin combination showed that significant increase in cognitive and conditions avoid response. Brain histological investigation of scopolamine injected rats showed neurodegeneration, Aβ plagues and odema. This combination improves biochemical parameters as well as in the histological feature of the brain as compare to the rivastigmine alone treated group. Conclusion: Aspirin and Rivastigmine combination possesses significant protective effect against neuroinflammation characterizing AD.

Keywords: Scopolamine, alzheimer’s, neuroinflammation, rivastigmine, aspirin.