Abstract

ROLE OF CARRIERS FOR ENHANCING SOLUBILITY OF SILVER SULFADIAZINE

Bigyan Joshi*, Arpana chaudhary, Pragya Pudasaini, Sristi Lamsal, Surachhya Sharma, Amit Shrestha and Sajan Maharjan

ABSTRACT

The present research work was aimed to enhance the solubility of Silver Sulfadiazine by solid dispersion approach. The study was carried out aiming firstly to increase the solubility and thus therapeutic action of silver sulfadiazine by preparing solid dispersions, secondly compare between formulated polyethylene glycol6000, polyvinyl pyrrolidone and mannitol varying the concentration of each polymer ratio of drug to the polymer was(1:1,1:2,1:3) and gelling agent, carbopol934 P(0.5% and 1%) for increasing the solubility using different techniques of solid dispersion formulation and thirdly carry out in-vitro diffusion study of optimized formulations. Solid dispersions of Silver Sulfadiazine were prepared by solvent evaporation method. Maximum Entrapment efficiency was of solid dispersions prepared with PEG 6000(1:2) corresponding to PVP and Mannitol.0.5% gel incorporated with PEG (1:2) showed to have the highest drug content (98.125%).

Keywords: Solid dispersion, silver sulfadiazine, solubility.