Abstract

NADPH OXIDASE INHIBITORS –ARE NOVEL DRUGS IN DIABETIC NEPHROPATHY A REVIEW

Dr. Navneet Omprakash Soni*

ABSTRACT

NADPH Oxidase are Novel drug in treatment of Diabetic Nephropathy. Purpose of study- The main purpose of the study was to find the Benefits of NADPH OXIDASE Inhibitors in Diabetic Nephropathy. Hypothesis – NADPH Oxidase inhibitor are novel drugs in treatment of Diabetic Nephropathy as they prevent podocyte injury, decreases extracellular matrix deposition, prevents epithelial mesenchymal transition, prevents mitochondrial injury, prevent antioxidant depletion, reduce ROS production in response to glucose and prevents signalling and activation of ERK and NF-κB activation decrease the expression of MCP-1 and prevent fibroblast proliferation and subsequently fibrosis. Method used –Various Quest engines and data base was used with sentence‘ NADPH Oxidase inhibitor in Diabetic Nephropathy’ and study ,report and evidences from previous articles were gathered to support the hypothesis. Results from search Engines- as on 11/07/2017. 1) Google: About 2,17,000 results (0.56 seconds). 2) Google Scholar: About 17,200 results (0.14 sec). 3) Pubmed: 2126. 4) Capto me: 1-10 of 8515774 records for NADPH Oxidase inhibitors in Diabetic Nephropathy - Pharmacology (ADME). Conclusion: From various studies, data and report support the stated Hypothesis is factual. My Contribution in the review • In this review the above hypothesis and probable benefit NADPH Oxidase Inhibitors are well supported from the available data and study. • All the scattered data and study about NADPH Oxidase role in pathogenesis of Diabetic Nephropathy is taken into consideration to support the hypothesis. • All the researcher and Scholar have done the best and I give credit to them but after going through various quest engines and articles so many articles huge data is generated which is not helpful, the review article provides comprehensive and core material. • The advantages of NADPH Oxidase Inhibitors are well elaborated in 1 to 13 points with strong study support and evidence using 25 articles to support the study.

Keywords: NADPH Oxidase , Podocyte injury, Diabetic Nephropathy.