![]() |
|||||||||||||
|
All | Since 2019 | |
Citation | 5450 | 3969 |
h-index | 23 | 20 |
i10-index | 134 | 84 |
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME PYRAZOLE DERIVATIVES FOR ANTI-INFLAMMATORY ACTIVITY
M. SajaniRaju*, E. Venkatanagaraju, Amit Kumar Das, K. Sumesh,C. Swetha and
ABSTRACT This work has been undertaken for the synthesis and pharmacological evaluation of some pyrazole derivatives for anti-inflammatory activity. 3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one obtained from phenyl hydrazine and ethyl acetoacetate was acetylated and then subjected to Claisen-Schmidt condensation with 4-hydroxy benzaldehyde to get a chalcone. This chalconewas cyclized with the help of hydroxylamine hydrochloride to form an isoxazole derivatives which were further condensed with various substituted aromatic aldehydes to obtain titled compounds (4aD1-4aD15). The structures of new synthesized compounds were confirmed by IR, 1H NMR and Mass spectral data. Synthesized derivatives were evaluated for their anti-inflammatory activity. The compound 4aD3, 4aD8, 4aD9, 4aD10 and 4aD14was found to have comparable anti-inflammatory activity with that of standard drug indomethacin. Keywords: Pyrazoles,synthesis,anti-inflammatory,indomethacin. [Download Article] [Download Certifiate] |