Abstract

A REVIEW ON DRUG INDUCED HEPATOTOXICITY AND ITS MANAGEMENT BY HERBAL DRUGS

Gurudeo N. Singh* Neeraj Kumar

ABSTRACT

The liver plays vital functions in maintaining, performing and regulating the homeostasis of body and it involves in almost all biochemical pathways such as nutrient supply, reproduction, biotransformation, energy supply and growth. The liver metabolize, detoxify and activate exogenous as well as endogenous compound and is capable for transforming foreign chemicals as it has high level of enzymatic system. Liver disorder or injury is defined as conditions, diseases, or infections that influence the structure and/or function of liver and this can lead to pathophysiological changes which may results in many liver dysfunction such as hepatitis, cirrhosis etc. In US, drug induced hepatotoxicity is the main reason behind withdrawal and non-approval of drugs by FDA. The drug induced hepatotoxicity may divided into acute reactions (hepatocellular necrosis); cholestasis (with or without inflammation); and miscellaneous reactions. Documentation and analysis of various case reports and case series suggested many drugs are hepatotoxic such as isoniazid, rifampicin, halothane, chlorpromazine, amoxicillin-clavulanic acid etc. In early researches on DILI, Chlorpromazine & Halothane were commonly reported cause of drug induced liver injury.

Keywords: Hepatotoxicity; Liver Injury; Hepatotoxic Drugs; Herbal Drugs.