Abstract

INHIBITORY ACTIVITY OF CHALCONE MOETIES ON PANCREATIC LIPASE ENZYME: A REVIEW

Muralidharan Palayyan* and Gejalakshmi Subramanian

ABSTRACT

The main challenge of today’s research is to design a novel drug for the treatment of ailments with lesser side effects. Obesity derives from Latin word obesities which means tout, fat, or plump. Medically, obesity is a condition in which excess body fat has been accumulated to the extent that it may have an adverse effect on health, leading to reduced life expectancy or increased health problems. Improper lipid metabolism adds other disorders like diabetes, musculoskeletal, cardiovascular and leads to cancer. Improper balance between energy intake and energy expenditure leads to obesity. The major target for the development of antiobesity drug is to inhibit the action of pancreatic lipase enzyme. Chalcones and their heterocyclic analogues, belong to the flavanoid family, which possess a number of interesting biological properties such as antioxidant, cytotoxic, anticancer, antimicrobial, antiprotozoal, antiulcer, antihistaminic and anti-inflammatory activities. In this review, an attempt is made to present a current scenario of the bioactive compounds from chalcone moieties possessing diverse electron-donating and -withdrawing groups were prepared that have been investigated for their pancreatic lipase inhibition. The purpose of this review is to provide an overview of the inhibitory activity of naturally occurring and synthetic chalcones on pancreatic lipase enzyme.

Keywords: Pancreatic lipase inhibitors, chalcones, antiobesity activity.