Abstract

SYNTHESIS CHARACTERIZATIONS & EVALUATIONS OF NEW ACRIDINES AS ANTIMICROBIALS

Yogesh Kumar Sharma* and Prof. (Dr.) Rakesh Kumar Jat

ABSTRACT

Resistance to anti-infective agents is a serious problem. Bacterial resistance continues to develop and poses a significant threat, both in hospitals and in the community.[8] Owing to the extended use and misuse of antibiotics, the number of bacteria that are resistant to antimicrobial agents is rapidly increasing. The rising prevalence of multi-drug resistance has become a serious health care problem and one of the organisms rapidly developing resistance is S. aureus. Infections caused by S aureus are as follows: septicemia, endocarditis, urinary tract infections, impetigo, abscesses, boils, carbuncles, meningitis, osteomyelitis, pneumonia, empyema, arthritis, enteritis, endophthalmitis. S. aureus accounts for more than 10% of nosocomial infections and about 20% of food-borne disease outbreaks. In hospitals, S. aureus causes 10% of infections on surgical services, 20% on pediatric services, and 35% in nurseries. The most important community-acquired staphylococcal infection is food poisoning. It is evident from the statistics that S aureus has significant pathogenic activity. it was observed that anti-microbials in the process of drug development reflects the increased interest in the field of infectious diseases and demonstrates that, although some progress has been made, further efforts are necessary to develop more promising agents. Hopefully, these agents will overcome limitations of existing classes and will achieve the delicate balance between broad spectrum of activity and target selectivity.

Keywords: Broad spectrum of activity, Target selectivity, Sufficient grade of selectivity, Need of new agents, Drug resistance, Overuse of antibiotics.