Abstract

A PROSPECTIVE STUDY ON THE USAGE OF METFORMIN AND AWARNESS OF LIFESTYLE MODIFICATION IN POLYCYSTIC OVARY SYNDROME AT VARIOUS HOSPITALS, PALAKKAD

Renatt C. Francis* and C. I. Sajeeth

ABSTRACT

Aim and Objectives: To monitor and assess the usage of metformin and awareness of life style modification in PCOS. Materials and Methods: A prospective study was conducted in various hospitals of Palakkad from November 2016- April 2017. A total of 207 cases were collected, in which 53cases were given metformin for treatment of PCOS Patients of age between 15-50years with polycystic ovary syndrome were included in the study. Results and Discussion: Out of 207 PCOS patients 50 patients have metformin therapy in which 68% were married, and remaining 32% were unmarried. In the present study, after administration of metformin the mean FSH level was decreased from 8.2±3.5 mIU/ml to 7.4±3.5 mIU/ml, the mean LH level was decreased from 8.0±4.2mIU/ml to 7.2±4.3 mIU/ml, and the mean prolactin level was decreased from 26.3±6.4 ng/ml to 22.2±6.5 ng/ml. 47.1% of the PCOS patients consuming metformin therapy were overweight. 41.5% of study population consuming metformin therapy were obese. Major concern of this study participants being irregular periods (27%), followed by abnormal hair growth (25%), acne (22.4%), and dark skin (21.8%) and remaining is difficulty in pregnancy (3%) etc. Life style modification include diet and exercise have major role in reducing the complications of disease. Conclusion: From this study it was clear that after administration of metformin, it shows significant decrease in the biochemical parameters like prolactin, FSH, LH etc No adverse reactions were recorded for the use of Metformin. So it is safe drug for obese PCOS patients. Efforts need to intensify creating awareness on the general public about PCOS, to improve the awareness about the disease.

Keywords: PCOS, Metformin, Awareness, Life style modification.