Abstract

“SIGNIFICANCE OF GAMMA GLOBULINS IN MULTIPLE MYELOMA THROUGH SERUM ELECTROPHORETIC PATTERN”

*Dutta Amit Kumar and Mukherjee Arpita

ABSTRACT

Multiple Myeloma (MM) is a neoplasm of B cell lineage which is characterized by excessive proliferation of abnormal plasma cells which secrete excess amount of immunoglobulin. The present paper focus on the expression of gamma globulin levels in patients suffering from multiple myeloma. SPEP is a simple lab technique where the serum is applied on a support medium and exposed to an electric current. The different fractions of the serum proteins separate usually into 5 bands, as – the albumin, α1, α2, β, and the γ globulin fractions. In the interpretation of SPEP, more attention is given to the gamma region, which is mainly composed of Immunoglobulin. Plasma protein levels display prominent changes in response to acute inflammation, malignancy, trauma and chemical injury. Apart from SPEP, immunofixation is used to predict result in case of very low concentration of immunoglobulin.

Keywords: Multiple Myeloma, SPEP, ?-globulin, Paper Electrophoresis, Immune-fixation.