Abstract

USE OF BACTERIOCIN FROM PROBIOTIC ISOLATE LACTOBACILLUS ACIDOPHILUS JD11 AS GERMICIDE IN THE TOOTH-PASTE FORMULATION.

Yagnik Bhupesh N.*, Jalpan J. Shah and Dhaval U. Gosai

ABSTRACT

Probiotics are live microorganisms exerting beneficial effects on host’s health. The present study shows isolation of Lactobacillus acidophilus strains from curd sample and its immobilization by encapsulation in sodium alginate. It is demonstrated that L. acidophilus strain under the encapsulated state can withstand harsh environmental condition mimicking that in human digestion tract by manipulating the low pH and high concentration of bile salt. The rampant use of antimicrobial have led to dispersal of resistance among the pathogens associated with humans, and adverse consequences of health and environment. Quest for safer health care product have led to the investigation of alternative antimicrobial agents to treat and prevent infections in both humans and animals. Research on antimicrobial peptides, with a special interest on bacteriocins of lactic acid bacteria, is entering a new era with novel applications other than food preservation. Development of novel application in medicinal and personal care products using these peptides is the current focus. One such product is suggested here and is given the name ‘probiotic toothpaste’ which is devoid of harsh chemical antimicrobial agents triclosan and fluoride. The first-hand comparision of using bacteriocin to replace chemical germicide has been reported as novel probiotic usage arena.

Keywords: Probiotics, Lactobacillus acidophilus, Encapsulation, Bacteriocin, Triclosan, Tooth-paste.