Abstract

DESIGN AND CHARACTERIZATION OF MICROEMULSION SYSTEMS FOR ETODOLAC

J. Hindu Manognya*, P. Sravani, Gazala Nousheen, V. Shirisha and Deva kumar

ABSTRACT

This research was aimed to formulate and characterize a microemulsion systems as a topical delivery system of Etodolac for relief of symptoms of rheumatoid arthritis, osteoarthritis and treatment of dysmenorrheal. Methods: ME formulations prepared by mixing of appropriate amount of surfactant including Tween 80 and Span 80, co-surfactant such as propylene glycol (PG) and oil phase. The prepared microemulsions were evaluated regarding their particle size, zeta potential, viscosity, differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and pH. Results: The mean droplets size of microemulsion formulation were in the range of 7.03 to 79.8 nm, and pH is 6.75. Viscosity range was 253.73- 802.63cps. Drug release profile showed that 26.15% of the drug released in the first 24 hours of experiment. Also, Hexagonal and bicontinuous structures were seen in the SEM photograph of the microemulsions. Conclusion: characterization, physicochemical properties and in vitro release were dependent upon the contents of S/C ratio, water and, oil phase percentage in formulations. Also, ME-6 may be preferable for topical etodolac formulation.

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