Abstract

ANTI-INFLAMMATORY AND HEALING POTENTIAL OF PHYTODERIVATIVES IN CUTANEOUS RABBITS WOUNDS

Marcelo Augusto Filardi*, Gabrielle Lück de Araújo, Tânia Toledo de Oliveira, Marcelo Rocha da Costa, Marilane Kalyetta de Almeida Fonseca and Liovando Marciano da Costa

ABSTRACT

Although there is a large use of medicinal plants in folk medicine, there are no studies involving the anti-inflammatory and healing effects of Achyrocline satureioides, Vernonia polyanthes, Plantago major, Cinnamomum camphora and Myroxylon peruiferum, combined or not, in the developed methodology. Tests were conducted in rabbits receiving ointment and gel on a dorsal-cervical wound at different concentrations and combinations of extracts from the cited plants, besides a registered commercial phytocomplex. The cream formulations of A. satureioides, C. camphora, P. major, M. peruiferum and V. polyanthes presented final concentrations of up to 4%, the gel formulations containing combined phytoderivatives had final concentrations of up to 10% for the mixture of four phytoderivatives (A. satureioides; P. major; M. peruiferum; V. polyanthes) or five phytoderivatives (C. camphora additional). In the hematological analysis, the treatment with the phytoderivative containing extract of the five plants at 10% was the one with the highest increase in plasma levels of protein and albumin, and caused the greatest reduction in calcium levels. Furthermore, this formulation was more efficient in promoting the formation of keratin in greater quantity and in an orderly way than the concentration of 1%. The formulation with the phytoderivative containing extract of four plants at 3% had a better anti-inflammatory effect. It was observed that the plants alone did not have the same effect as the combined formulations confirming the synergistic phytochemical effect between extracts. For the first time, ointments and gels manipulated from extracts of these plants contributed to a control of the inflammatory process and many with considerably better results than the commercial phytocomplex.

Keywords: phytomedicines, cutaneous wounds, anti-inflammatory, phytoderivates, biochemical screening, histological analysis.