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ANTIDIABETIC ACTIVITY OF ILER (Plectranthus scutellarioides (L.) R. Br.) LEAVES SUBFRACTIONS OF ETHYL ACETATE FRACTION IN ALLOXAN-INDUCED DIABETIC MICES
Adilah Salaeh*, Yasmiwar Susilawati, Sri Adi Sumiwi and Moelyono Moektiwardoyo
ABSTRACT
(Plectranthus scutellarioides (L.) R.Br.) leaves of extracts ethanol were previously shown to antidiabetic activity and the ethyl acetate fraction showed the highest activity of antidiabetic. The present study was undertaken to investigate the subfractions of ethyl acetate fraction of iler leaves which has the best antidiabetic activity. Diabetes was induced in mice by single intraperitoneal administration of alloxan monohydrate (255 mg/kg bw). Control normal group, as well as diabetic mice were divided into groups (n=4) receiving different treatments. Doses (100 mg/kg bw) of PSS 1, PSS 2, PSS 3 and PSS 4 were studied in alloxan-induced diabetic mices for a period of 8 days. Keywords: Iler (Plectranthus scutellarioides), Antidiabetic, Mice, Alloxan. [Download Article] [Download Certifiate] |