Abstract

HEPATOPROTECTIVE EFFECTS OF PHYLLANTHUS VASUKII PARTHIPAN ET AL. (PHYLLANTHACEAE) AGAINST CCL4 INDUCED HEPATOTOXICITY IN RATS

*Jemimma H. L., Arumugasamy K., Nantha Kumar R., Abdul Kaffor H. and Kirthika N.

ABSTRACT

The aim of the present study is to investigate the hepatoprotective activity of Phyllanthus vasukii ethanol root extract against Carbon tetrachloride (CCl4) intoxicated rats, which showed significant elevation in serum enzymes, bilirubin and lipid peroxidation of the liver tissues, SGOT, SGPT and ALP and reduction in body weight, serum total protein, SOD, CAT, GRD,GSH and GPx activity. Treatment with ethanol extract of P. vasukii plant altered the above parameters to the levels of near normal. All the above results were comparable with the standard drug silymarin (100 mg kg-1) treated group. Thus the present study ascertains that the ethanol root extract of P. vasukii possesses significant hepatoprotective activity.

Keywords: Hepatoprotective activity, Carbon tetrachloride (CCl4), serum enzymes, silymarin.