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Abstract

DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE PELLETS OF METOPROLOL TARTRATE

Mangesh R. Bhalekar*, Ashwini R. Madgulkar and Sumedha S. Andure

ABSTRACT

The objective of the study was to develop and evaluate sustained release Metoprolol tartrate pellets in the form capsule and compare with the marketed dosage form (METLOR-XR). The formulation was optimized using 32 factorial design by design expert software version 10.0. The concentration of Eudragit L-100 and concentration of PVP K-30 were chosen as independent variables. The formulated pellets were evaluated for flow properties, % drug content, in-vitro drug release, % coating efficiency, SEM, DSC and FTIR, etc. The optimized formulated batch was compared with the marketed formulation (METLOR-XR capsule). The % drug release of optimized batch hour was found to be 91.35%. The formulated batch (F1) has more drug release than marketed product and hence it has more bioavailability.

Keywords: Metoprolol tartrate, Eudragit L-100, Polyvinyl pyrrolidone k-30, Solution layering technique, pellets.


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