Abstract

"FORMULATION AND EVALUATION OF DENTAL ANALGESIC TABLET CONTAINING EUGENOL"

Nuha Rasheed*, Saniya Kousar, Soobiya Sultana, Shehnaz Begum, Mohammed Muddassir Mahmood, Mohammed Imran and Shaik Zubair

ABSTRACT

Clove is an herb. People use the oils, dried flower buds, leaves, and stems to make medicine. Clove seems likely safe for most people when taken by mouth in small amounts. Not enough is known about the safety of taking clove by mouth in larger medicinal amounts. The principal constituents of distilled clove bud oil (60% to 90%) are the phenylpropanoids, including primarily eugenol (4-allyl-2- methoxyphenol) and carvacrol, thymol, and cinnamaldehyde. The oil also contains approximately 10% acetyleugenol. Eugenol is a phenylpropene, an allyl chain-substituted guaiacol. Eugenol is a member of the phenylpropanoids class of chemical compounds. It is a colourless to pale yellow, aromatic oily liquid extracted from certain essential oils especially from clove. l It is present in concentrations of 80–90% in clove bud oil and at 82–88% in clove leaf oil. An optimized Dental analgesic tablet formulation containing clove, carbopol, dibasic calcium phosphate, microcrystalline cellulose, methyl paraben, peg 400 was successfully developed. The formulation 5 was best compared to all other formulations. The prepared tablet formulation F5 has disintegrated within 11min 25sec. The tablets passed the weight variation test the maximum weight variation of the tablet was ± 2.42% which falls within the acceptable range of ± 5%. The thickness of the tablets was found to be 5.02 mm2. The hardness of the tablets was 5.45 kg/cm2 which fall above the limit of not less than 3 kg/cm2, indicating good mechanical resistance of the tablets. Friability value for tablets was not more than 0.87%. On the basis of disintegration and wetting time results, the formulation F5 was best compared to all other formulations. The prepared tablet formulation F5 has disintegrated within 11 min 25 sec.

Keywords: Formulation, Evaluation, Eugenol, Clove, Analgesic, Tablet.