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FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF ZIDOVUDINE
Kamlesh A. Kadiya*, Dr. Anil S.Solanki, Dr. Vishnu M.Patel Dr. Anand K. Patel
ABSTRACT
The aim of the present study was to formulate and evaluate the fast dissolving tablets of zidovudine using superdisintegrants. Zidovudine an antiretroviral drug belonging to nucleosides reverse transcriptase inhibitor has achieved immense popularity in the treatment of HIV and AIDS related conditions. The advantage of ease of swallowing and no need of water has led to better acceptability amongst the dysphasic patient. FDTS of zidovudine were prepared by direct compression technique using natural and synthetic superdisintegrants and evaluated for pre-compression parameters like bulk density, tapped density, carr’s index, hausner ratio and post compression parameters like hardness, disintegration time, thickness, friability, wetting time, drug content, weight variation, in-vitro release, stability studies. FTIR Keywords: Zidovudine, Fast Dissolving Tablet, Sodium Starch Glycolate, Isapgula mucilage, direct compression. [Download Article] [Download Certifiate] |