Abstract

SOLUBILITY ENHANCEMENT OF CLOMIPHENE CITRATE USING NANOTECHNOLOGY

Mansuri Mohammadfarhan Mohammadharun*, Dr. Anil S. Solanki, Dr. Vishnu M. Patel and Dr. Anand K. Patel

ABSTRACT

The ambition of the present investigation is to improve solubility and dissolution rate of clomiphene citrate by nanotechnology (solvent diffusion metod) using mixture of pvp k – 30 and tween – 80. To prepare Nano suspension of optimized batch (FF6).The prepared Clomiphene citrate Nano suspension were characterized in term of Fourier transform infrared spectroscopy (FTIR), gas chromatography, particle size distribution, poly dispersity index (Zeta sizer), microscopic (SEM) studies, solubility, dissolution studies. The FTIR indicates no interaction between drug and polymer and no change in chemical nature. The aqueous solubility and dissolution rate of clomiphene citrate Nano suspension was significantly increased. The optimized Nano suspension after stability showed no significantchange in formulation that was same as before stability. The prepared Nano suspension of clomiphene citrate showed more solubility and in vitro drug release compared to marketed formulation.

Keywords: Clomiphene citrate, chitosan, PVP k - 30, PLGA, solvent diffusion method, Nano suspension, Nano technology, solubility enhancement.