Abstract

A REVIEW ON COORDINATION BEHAVIOUR AND BIOACTIVITY OF METAL COMPLEXES OF NICOTINIC ACID AND ITS DERIVATIVES

Suresh Kumar Verma and Narendar Bhojak*

ABSTRACT

Nicotinic acid and its derivatives are potent biological chelating ligands as most of them have N, S, and O donor atoms that can act as coordinating sites for metal ion coordination. Like these ligands, their metal complexes also have many important biological activities such as antibacterial, antifungal, antiviral, antitumor, anti-inflammatory etc. and are also found to be pharmacologically and physiologically active. Many such metal complexes of nicotinic acid and its derivatives have supramolecular association i.e. 3D framework structure via hydrogen or covalent bonds. The most relevant papers recently published are reviewed with an attempt to focus the bioactivity and structure of such metal complexes along with some related applications.

Keywords: Nicotinic acid, biological activity, hydrothermal, supramolecular, hydrogen bonds, schiff bases.