Abstract

A REVIEW ON PULSATILE SYSTEM CONSIDERING ANTI HYPERTENSIVE DRUGS

Shilpi Kashyap* and Aman Thakhur

ABSTRACT

Pulsatile drug delivery system is gaining increasing attention as it offers a more efficient approach to the traditional sustained drug delivery i.e. a constant amount of drug released per unit time or constant blood levels. An intelligent drug delivery system has a capability for the adjustment of release rates of drug with a response to physiological need. The principle rationale for the use of pulsatile release is for the drugs where a constant drug release i.e. a zero-order release is not desired. Pulsatile drug delivery system (PDDS) is characterized by a time period of no release (lag time) followed by a rapid (burst) and complete drug release. PDDS can be classified into time controlled systems wherein the drug release is controlled primarily by the delivery system, stimuli induced. PDDS in which release is controlled by the stimuli, such as the pH or enzymes present in the intestinal tract and externally regulated system where release is programmed by external stimuli like magnetism, ultrasound, electrical effect and irradiation. The current article focuses on the diseases requiring PDDS, methodologies involved for the existing systems, recent update and PDDS product currently available in market.

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